Growth Hormone Peptides Myostatin GDF-8 For Bodybuilding CAS 1621169-52-5

GDF-8 Infor

Product Name:GDF-8
Chemical Name:Growth Differentiation Factor 8
Other Names:Myostatin
CAS No.:901758-09-6
MF:C221H366N72O67S
Visual Appearance:White powder
Dry:Freeze
Purity: >98%

GDF-8 Description:

Myostatin (GDF-8) is a member of the transforming growth factor-beta (TGF-beta) superfamily that is highly expressed in skeletal muscle, and GDF-8 loss-of-function leads to doubling of skeletal muscle mass. GDF-8-deficient mice have been used as a model for studying muscle-bone interactions, and here we review the skeletal phenotype associated with altered GDF-8 signaling. It is now known that GDF-8 is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking the GDF-8 gene show decreased body fat and a generalized increase in bone density and strength.

The increase in bone density is observed in most anatomical regions, including the limbs, spine, and jaw, and GDF-8 inhibitors have been observed to significantly increase bone formation. GDF-8 is also expressed in the early phases of fracture healing, and GDF-8 deficiency leads to increased fracture callus size and strength. Together, these data suggest that GDF-8 has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that GDF-8 antagonists and inhibitors are likely to enhance both muscle mass and bone strength.

GDF-8 Application:

1.Myostatin (GDF-8), a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, GDF-8 circulates as part of a latent complex containing GDF-8 propeptide and follistatin-relatedgene.

2.The GDF-8 propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The GDF-8 propeptide is negative regulator of myostatin in vivo.

3.Animals either lacking GDF-8 or treated with substances that block the activity of GDF-8 have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the GDF-8 gene have significantly more muscle mass and are stronger than normal. Blocking the activity of GDF-8 may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.

Myostatin (GDF8) is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma. GDF-8 is a member of the transforming growth factor ß superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass. Studies have shown that GDF-8 could play an important role in cardiac development and physiology.

Are you GDF8 China supplier?

Yes, We are GDF8 China supplier and we can also supply other peptides.

How do you guarantee the GDF8 quality?

We have our GDF8 testing lab. 

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