ГВ-0742 Изграждане на мускулите Sarms суров прах за културизъм добавки Cas.317318-84-6

Име на продукта:ГВ0742
КАС:317318-84-6
Синоними GW0742;[4-[[[2-[3-ФЛУОРО-4-(ТРИФЛУОРОМЕТИЛ)ФЕНИЛ]-4-МЕТИЛ-5-ТИАЗОЛИЛ]МЕТИЛ]ТИО]-2-МЕТИЛФЕНОКСИ]ОЦЕТНА КИСЕЛИНА;4-[2-(3-ФЛУОРО-4-ТРИФЛУОРОМЕТИЛ-ФЕНИЛ)-4-МЕТИЛ-ТИАЗОЛ-5-ИЛМЕТИЛСУЛФАНИЛ]-2-МЕТИЛ-ФЕНОКСИ-ОЦЕТНА КИСЕЛИНА;4-[[[2-[3-Флуоро-4-(трифлуорометил)Фенил]-4-метил-5-тиазолил]метил]тио]-2-метилфенокси]Оцетна киселина;4-[2-(3-Флуоро-4-трифлуорометил-фенил)-4-метил-тиазол-5-илметилсулфанил]- 2-метил-фенокси}-оцетна киселина;Оцетна киселина, 2-[4-[[[2-[3-флуоро-4-(трифлуорометил)Фенил]-4-Метил-5-тиазолил]Метил]тио]-2-Метилфенокси]-;2-(4-(((2-(3-Флуоро-4-(трифлуорометил)Фенил)-4-метилтиазол-5-ил)метил)тио)-2-метилфенокси);GW 0742X
Чистота:99%
МФ:C21H17F4NO3S2
MW:471.49
МП:134.5-135.5 °C

GW0742 Descrption

ГВ0742, Известен още като GW610742, е PPAR агонист. GW0742 индуцира ранно невронно съзряване на кортикалните постмитотични неврони. GW0742 предотвратява хипертонията, съдов възпалителен и оксидативен статус, и ендотелна дисфункция при затлъстяване, предизвикано от диетата. GW0742 has direct protective effects on right heart hypertrophy.GW0742 may enhance lipid metabolism in heart both in vivo and in vitro.

GW0742 Application

GW0742 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue , and GW501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome , most likely by stimulating fatty acid oxidation.

GW0742 has been proposed as a potential treatment for obesity and related conditions , especially when used in conjunction with a synergistic compound AICAR , as the combination has been shown to significantly increase exercise endurance in human.

How GW0742 Works?

The highest antagonist activity for GW0742 was found for VDR and the androgen receptor (АР). Surprisingly, GW0742 behaved as PPAR agonist/antagonist activating transcription at lower concentration and inhibiting this effect at higher concentrations. A unique spectroscopic property of GW0742 was identified as well. In the presence of rhodamine-derived molecules, GW0742 increased fluorescence intensity and fluorescence polarization at an excitation wavelength of 595 nm and emission wavelength of 615 nm in a dose dependent manner.

The GW0742-inhibited NR-coactivator binding resulted in a reduced expression of five different NR target genes in LNCaP cells in the presence of agonist. Especially VDR target genes CYP24A1, IGFBP-3 and TRPV6 were negatively regulated by GW0742. GW0742 is the first VDR ligand inhibitor lacking the secosteroid structure of VDR ligand antagonists. Nevertheless, the VDR-meditated downstream process of cell differentiation was antagonized by GW0742 in HL-60 cells that were pretreated with the endogenous VDR agonist 1,25-dihydroxyvitamin D3.

Are you GW0742 manufacuter?

Да, our company can supply a varity of sarms products including GW0742.

How do you guarantee the GW0742 quality?

We have our own testing center, we can test the quality of GW0742.

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